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KMID : 0545120150250040492
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Journal of Microbiology and Biotechnology
2015 Volume.25 No. 4 p.492 ~ p.495
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Expression of the mexA Gene Requires the DNA Helicase RecG in Pseudomonas aeruginosa PAO1
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Heo A-Ram
Park Woo-Jun
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Abstract
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This study provides evidence that RecG regulates the expression of the OxyR-independent gene mexA in Pseudomonas aeruginosa PAO1. A reduction in mexA expression was observed in the absence of RecG, but not OxyR, by northern blot and quantitative real-time PCR analyses. The canonical palindromic RecG binding sequence was present upstream of the mexA promoter, and bound purified RecG and single strand-binding protein. These data reveal a novel mechanism of OxyR-independent gene transcription by RecG.
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KEYWORD
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DNA helicase RecG, OxyR, Pseudomonas aerruginosa, efflux pump, mexA, transcriptional regulator
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